iPTMnet Report for Q9NWY4 (HPF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NWY4 / HPF1_HUMAN
Protein Name Histone PARylation factor 1
Gene Name Name: HPF1
Synonyms:C4orf27;
Organism Homo sapiens (Human)

PRO ID PR:Q9NWY4
DAG View
PRO Name histone PARylation factor 1 (human)
Definition A histone PARylation factor 1 that is encoded in the genome of human.
Short Label hHPF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NWY4 (HPF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K19 Ubiquitination PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K186 Acetylation PhosphoSitePlus   UniProt 19608861
K186 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T193 O-Glycosylation GlyGen 30379171
K220 Ubiquitination PhosphoSitePlus
K233 Acetylation PhosphoSitePlus   UniProt 19608861
K233 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K27 N27 Biomuta DOID:1324 / lung cancer [ cosmic ]
K149 N149 Biomuta DOID:363 / uterine cancer [ icgc ]
K150 T150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K249 N249 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]