iPTMnet Report for Q9NWX6 (THG1L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NWX6 / THG1_HUMAN
Protein Name Probable tRNA(His) guanylyltransferase
Gene Name Name: THG1L
Synonyms:ICF45;
Organism Homo sapiens (Human)

PRO ID PR:Q9NWX6
DAG View
PRO Name probable tRNA(His) guanylyltransferase (human)
Definition A probable tRNA(His) guanylyltransferase that is encoded in the genome of human.
Short Label hTHG1L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NWX6 (THG1L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S33 O-Glycosylation GlyGen 30379171
C51 Methylation IEDB 31844290
K68 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
C180 Methylation IEDB 31844290
S222 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y228 Phosphorylation HPRD   PhosphoSitePlus 20068231
T239 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K263 Acetylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
C279 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K170 N170 Biomuta DOID:1319 / brain cancer [ icgc ]
Y228 H228 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K264 R264 Biomuta DOID:1319 / brain cancer [ cosmic ]