iPTMnet Report for Q9NWF9 (RNF216)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NWF9 / RN216_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF216
Gene Name Name: RNF216
Synonyms:TRIAD3,UBCE7IP1,ZIN;
Organism Homo sapiens (Human)

PRO ID PR:Q9NWF9
DAG View
PRO Name E3 ubiquitin-protein ligase RNF216 (human)
Definition An E3 ubiquitin-protein ligase RNF216 that is encoded in the genome of human.
Short Label hRNF216
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NWF9 (RNF216) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K351 Sumoylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K354 Sumoylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus   UniProt 23186163
K425 Acetylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
Y437 Phosphorylation PhosphoSitePlus
K448 Sumoylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K485 Sumoylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
C530 Methylation IEDB 31844290
K538 Ubiquitination PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K589 Sumoylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
K619 Sumoylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K658 Sumoylation PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
K666 Sumoylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
Y710 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus   UniProt 34998453
K749 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K777 Sumoylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 17924679
K80 Sumoylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K89 Methylation PhosphoSitePlus
K89 Sumoylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S476 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 17924679
S419 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K391 M391 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K459 M459 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K619 N619 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K658 E658 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S719 T719 Biomuta DOID:3571 / liver cancer [ cosmic ]