iPTMnet Report for Q9NW38 (FANCL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NW38 / FANCL_HUMAN
Protein Name E3 ubiquitin-protein ligase FANCL
Gene Name Name: FANCL
Synonyms:PHF9;
Organism Homo sapiens (Human)

PRO ID PR:Q9NW38
DAG View
PRO Name E3 ubiquitin-protein ligase FANCL (human)
Definition An E3 ubiquitin-protein ligase FANCL that is encoded in the genome of human.
Short Label hFANCL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NW38 (FANCL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
T4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
C12 Methylation IEDB 31844290
K22 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
C132 Methylation IEDB 31844290
K139 Sumoylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus   RLIMS-P 23783032
K218 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
C362 Methylation IEDB 31844290
K364 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 S4 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S7 G7 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K49 N49 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K139 Q139 Biomuta DOID:363 / uterine cancer [ icgc ]