iPTMnet Report for Q9NVX2 (NLE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NVX2 / NLE1_HUMAN
Protein Name Notchless protein homolog 1
Gene Name Name: NLE1
ORFNames:HUSSY-07;
Organism Homo sapiens (Human)

PRO ID PR:Q9NVX2
DAG View
PRO Name notchless protein homolog 1 (human)
Definition A notchless protein homolog 1 that is encoded in the genome of human.
Short Label hNLE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NVX2 (NLE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
T40 Phosphorylation PhosphoSitePlus
S79 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
Y128 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T40 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 17525332
Y128 Phosphorylation HPRD 20068231
S131 Phosphorylation HPRD 20068231
S133 Phosphorylation HPRD 20068231
T136 Phosphorylation HPRD 20068231
T137 Phosphorylation HPRD 20068231
T246 Phosphorylation HPRD 20068231
S381 Phosphorylation HPRD 20068231
S384 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation HPRD 20068231
S92 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K176 M176 Biomuta DOID:1324 / lung cancer [ cosmic ]
K224 R224 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K439 N439 Biomuta DOID:9256 / colorectal cancer [ cosmic ]