iPTMnet Report for Q9NVW2 (RLIM)
Protein Information
| UniProt AC / UniProt ID | Q9NVW2 / RNF12_HUMAN |
| Protein Name | E3 ubiquitin-protein ligase RLIM |
| Gene Name | Name: RLIM Synonyms:RNF12; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9NVW2 |
| PRO Name | E3 ubiquitin-protein ligase RLIM (human) |
| Definition | An E3 ubiquitin-protein ligase RLIM that is encoded in the genome of human. |
| Short Label | hRLIM |
| Category | organism-gene |
Q9NVW2 (RLIM) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| K9 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S21 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R117 | Methylation | score1 | PhosphoSitePlus | |||
| S132 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S164 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S181 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S185 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S191 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S195 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S215 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S228 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S230 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
| S236 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S276 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S295 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S347 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T349 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T353 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R360 | Methylation | score1 | PhosphoSitePlus | |||
| R364 | Methylation | score1 | PhosphoSitePlus | |||
| S459 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S460 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S461 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S462 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S463 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S468 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S469 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S470 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S471 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S503 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S505 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S506 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K550 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K568 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K582 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K585 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C588 | Methylation | score1 | IEDB | 31844290 | ||
| C596 | Methylation | score1 | IEDB | 31844290 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R117 | K117 | Biomuta | DOID:1612 / breast cancer [ icgc ] | |
| R117 | I117 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| S276 | A276 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| T349 | K349 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T353 | I353 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| R360 | Q360 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S459 | L459 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S470 | R470 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S471 | P471 | Biomuta | [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
| C588 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
DAG View