iPTMnet Report for Q9NVV4 (MTPAP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NVV4 / PAPD1_HUMAN
Protein Name Poly(A) RNA polymerase, mitochondrial precursor
Gene Name Name: MTPAP
Synonyms:PAPD1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NVV4
DAG View
PRO Name poly(A) RNA polymerase, mitochondrial (human)
Definition A poly(A) RNA polymerase, mitochondrial that is encoded in the genome of human.
Short Label hMTPAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NVV4 (MTPAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K90 Acetylation PhosphoSitePlus   UniProt 19608861
K90 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
C225 Methylation IEDB 31844290
S262 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
C412 S-Nitrosylation dbSNO 26338901
C419 S-Nitrosylation dbSNO 26338901
K429 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
K562 Methylation PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S166 Phosphorylation HPRD 19691289
Site PTM Type PTM Enzyme Score Source PMID
K132 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 A64 Biomuta DOID:3571 / liver cancer [ cosmic ]
C419 Y419 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K429 T429 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K468 T468 Biomuta DOID:363 / uterine cancer [ icgc ]
K548 T548 Biomuta DOID:363 / uterine cancer [ icgc ]
T553 K553 Biomuta DOID:3571 / liver cancer [ cosmic ]
K555 R555 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S560 F560 Biomuta DOID:4159 / skin cancer [ cosmic ]
S560 Y560 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K562 Q562 Biomuta DOID:9256 / colorectal cancer [ cosmic ]