Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NVU0 / RPC5_HUMAN
Protein Name DNA-directed RNA polymerase III subunit RPC5
Gene Name Name: POLR3E
Organism Homo sapiens (Human)

DAG View
PRO Name DNA-directed RNA polymerase III subunit RPC5 (human)
Definition A DNA-directed RNA polymerase III subunit RPC5 that is encoded in the genome of human.
Short Label hPOLR3E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NVU0 (POLR3E) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
S161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569, ...19690332
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 17525332, ...24275569
S192 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y224 Phosphorylation PhosphoSitePlus   UniProt 19690332
T236 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K383 Acetylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K465 Methylation PhosphoSitePlus
K467 Methylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K498 Sumoylation PhosphoSitePlus
S503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S522 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S528 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
K659 Sumoylation PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S161 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S162 Phosphorylation HPRD 19651622, 17525332, 18669648
S503 Phosphorylation HPRD 19651622, 18669648, 18452278
S522 Phosphorylation HPRD 18669648, 18452278

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K376 R376 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K376 T376 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K383 N383 Biomuta DOID:363 / uterine cancer [ tcga ]
K432 R432 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]