iPTMnet Report for Q9NVR0 (KLHL11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NVR0 / KLH11_HUMAN
Protein Name Kelch-like protein 11 precursor
Gene Name Name: KLHL11
Organism Homo sapiens (Human)

PRO ID PR:Q9NVR0
DAG View
PRO Name kelch-like protein 11 (human)
Definition A kelch-like protein 11 that is encoded in the genome of human.
Short Label hKLHL11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NVR0 (KLHL11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S113 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus   UniProt 23186163
K469 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 L113 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y121 H121 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K142 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S445 Y445 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K452 E452 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S486 L486 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K489 R489 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K495 E495 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K521 N521 Biomuta DOID:363 / uterine cancer [ icgc ]