iPTMnet Report for Q9NVC6 (MED17)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NVC6 / MED17_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 17
Gene Name Name: MED17
Synonyms:ARC77,CRSP6,DRIP77,DRIP80,TRAP80;
Organism Homo sapiens (Human)

PRO ID PR:Q9NVC6
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 17 (human)
Definition A mediator of RNA polymerase II transcription subunit 17 that is encoded in the genome of human.
Short Label hMED17
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NVC6 (MED17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
S37 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S50 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S152 Phosphorylation RLIMS-P 33596087
K162 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S185 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K202 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K361 Acetylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
Y637 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation HPRD 17525332
T143 Phosphorylation HPRD 18691976
S185 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T143 M143 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S185 F185 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K226 N226 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K235 Q235 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S408 L408 Biomuta DOID:9256 / colorectal cancer [ cosmic ]