iPTMnet Report for Q9NV70 (EXOC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NV70 / EXOC1_HUMAN
Protein Name Exocyst complex component 1
Gene Name Name: EXOC1
Synonyms:SEC3,SEC3L1;ORFNames:BM-012;
Organism Homo sapiens (Human)

PRO ID PR:Q9NV70
DAG View
PRO Name exocyst complex component 1 (human)
Definition An exocyst complex component 1 that is encoded in the genome of human.
Short Label hEXOC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NV70 (EXOC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Acetylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
Y400 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus   UniProt 24275569
T471 Phosphorylation PhosphoSitePlus   UniProt 21406692
S472 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S473 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S478 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus   UniProt 19690332
S489 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T559 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
K700 Acetylation PhosphoSitePlus
K704 Acetylation PhosphoSitePlus
Y769 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
Y800 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T43 Phosphorylation HPRD 20068231
Y400 Phosphorylation HPRD 20068231
T445 Phosphorylation HPRD 18212344
S470 Phosphorylation HPRD 19651622, 18669648, 20068231
T471 Phosphorylation HPRD 19413330, 19651622, 20068231
S472 Phosphorylation HPRD 19651622, 20068231
S473 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S487 Phosphorylation HPRD 20068231
S489 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T43 Phosphorylation HPRD 20068231
Y400 Phosphorylation HPRD 20068231
S448 Phosphorylation PhosphoSitePlus
S449 Phosphorylation HPRD   PhosphoSitePlus 17081983
S455 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
T456 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 20068231
S457 Phosphorylation HPRD 19651622, 20068231
S458 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 18669648, ...20068231
S472 Phosphorylation HPRD 20068231
S474 Phosphorylation HPRD 18452278
K685 Acetylation PhosphoSitePlus
K689 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K402 R402 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S449 L449 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
T456 A456 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T471 A471 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S482 L482 Biomuta DOID:4159 / skin cancer [ cosmic ]
S482 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S482 A482 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T568 I568 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y769 N769 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y769 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y800 * Biomuta DOID:3571 / liver cancer [ cosmic ]