Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NV66 / TYW1_HUMAN
Protein Name S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
Gene Name Name: TYW1
Synonyms:RSAFD1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NV66
DAG View
PRO Name S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (human)
Definition An S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 that is encoded in the genome of human.
Short Label hTYW1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NV66 (TYW1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K52 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K170 Methylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
R391 Methylation PhosphoSitePlus
K396 Acetylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K505 T505 Biomuta DOID:363 / uterine cancer [ tcga ]
K566 R566 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S692 N692 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K694 R694 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]