iPTMnet Report for Q9NUW8 (TDP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NUW8 / TYDP1_HUMAN
Protein Name Tyrosyl-DNA phosphodiesterase 1
Gene Name Name: TDP1
Organism Homo sapiens (Human)

PRO ID PR:Q9NUW8
DAG View
PRO Name tyrosyl-DNA phosphodiesterase 1 (human)
Definition A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human.
Short Label hTDP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NUW8 (TDP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 O-Glycosylation GlyGen 30379171
S2 Phosphorylation PhosphoSitePlus
T11 O-Glycosylation GlyGen 30379171
T11 Phosphorylation phospho.ELM 17081983
S13 O-Glycosylation GlyGen 30379171
S13 Phosphorylation phospho.ELM 17081983
S14 O-Glycosylation GlyGen 30379171
S14 Phosphorylation phospho.ELM 17081983
S15 O-Glycosylation GlyGen 30379171
S15 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S18 O-Glycosylation GlyGen 30379171
S18 Phosphorylation PhosphoSitePlus
K22 Sumoylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S61 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S79 Phosphorylation PhosphoSitePlus
S81 Phosphorylation Q13315 (ATM) , P78527 (PRKDC) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17478428, 19851285, 29078113, ...24637157
S90 Phosphorylation phospho.ELM 17081983
S91 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM 19851285, 17081983
S92 Phosphorylation phospho.ELM 17081983
K112 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S148 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T169 O-Glycosylation GlyGen 30379171
S172 O-Glycosylation GlyGen 30379171
K222 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
R361 Methylation PhosphoSitePlus
S365 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
K367 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S563 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
R586 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 17081983
S13 Phosphorylation HPRD 17081983
S14 Phosphorylation HPRD 17081983
S15 Phosphorylation HPRD 17081983
S61 Phosphorylation HPRD 18669648, 20068231
S79 Phosphorylation HPRD 17081983
S81 Phosphorylation HPRD 17081983
S92 Phosphorylation HPRD 17081983
T147 Phosphorylation HPRD 18669648, 20068231
S148 Phosphorylation HPRD 18669648, 20068231, 18452278
S518 Phosphorylation HPRD 18452278
S563 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T11 S11 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S13 F13 Biomuta DOID:1324 / lung cancer [ cosmic ]
S18 C18 Biomuta DOID:1324 / lung cancer [ cosmic ]
S18 N18 Biomuta DOID:3571 / liver cancer [ cosmic ]
S61 L61 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S79 C79 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S81 F81 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S92 G92 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S434 Y434 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S518 A518 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R586 W586 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]