iPTMnet Report for Q9NUV7 (SPTLC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NUV7 / SPTC3_HUMAN
Protein Name Serine palmitoyltransferase 3
Gene Name Name: SPTLC3
Synonyms:C20orf38,SPTLC2L;
Organism Homo sapiens (Human)

PRO ID PR:Q9NUV7
DAG View
PRO Name serine palmitoyltransferase 3 (human)
Definition A serine palmitoyltransferase 3 that is encoded in the genome of human.
Short Label hSPTLC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NUV7 (SPTLC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S145 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K273 Methylation PhosphoSitePlus
K282 Sumoylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S145 L145 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S145 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K185 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S340 G340 Biomuta DOID:363 / uterine cancer [ icgc ]
S547 R547 Biomuta DOID:363 / uterine cancer [ icgc ]