iPTMnet Report for Q9NUQ9 (CYRIB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NUQ9 / CYRIB_HUMAN
Protein Name CYFIP-related Rac1 interactor B
Gene Name Name: CYRIB
Synonyms:CYRI;ORFNames:BM-009;
Organism Homo sapiens (Human)

PRO ID PR:Q9NUQ9
DAG View
PRO Name CYFIP-related Rac1 interactor B (human)
Definition A CYFIP-related Rac1 interactor B that is encoded in the genome of human.
Short Label hCYRIB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NUQ9 (CYRIB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 30250061, 25255805
Y36 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
R57 Methylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus   UniProt 31285585
K78 Ubiquitination PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S188 Phosphorylation HPRD 20068231
Y191 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
G2 W2 Biomuta DOID:1612 / breast cancer [ cosmic ]
G2 E2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R57 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R57 T57 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K74 N74 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K91 N91 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
K146 N146 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K207 N207 Biomuta DOID:1324 / lung cancer [ cosmic ]