iPTMnet Report for Q9NUM4 (TMEM106B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NUM4 / T106B_HUMAN
Protein Name Transmembrane protein 106B
Gene Name Name: TMEM106B
Organism Homo sapiens (Human)

PRO ID PR:Q9NUM4
DAG View
PRO Name transmembrane protein 106B (human)
Definition A transmembrane protein 106B that is encoded in the genome of human.
Short Label hTMEM106B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NUM4 (TMEM106B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
K3 Ubiquitination PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
Y18 Phosphorylation HPRD   PhosphoSitePlus 19901323
S33 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
Y50 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 19901323, 17016520
S58 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
N145 N-Glycosylation GlyGen   UniProt 22511793
N151 N-Glycosylation GlyGen   UniProt 22511793
N164 N-Glycosylation GlyGen   UniProt 22511793
N182 N-Glycosylation GlyGen 24190977
N183 N-Glycosylation GlyGen   UniProt 23742080, 19159218, 24190977, ...23090970, 22511793, 29741879
T185 O-Glycosylation GlyGen 36240223, 34725712, 34019948, ...28657654
N223 N-Glycosylation GlyGen 29741879
C253 Methylation IEDB 33981976, 31844290
N256 N-Glycosylation GlyGen   UniProt 29741879, 22511793
Y266 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 C4 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y50 C50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S58 C58 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y135 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T185 S185 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]