iPTMnet Report for Q9NTJ3 (SMC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NTJ3 / SMC4_HUMAN
Protein Name Structural maintenance of chromosomes protein 4
Gene Name Name: SMC4
Synonyms:CAPC,SMC4L1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NTJ3
DAG View
PRO Name structural maintenance of chromosomes protein 4 (human)
Definition A structural maintenance of chromosomes protein 4 that is encoded in the genome of human.
Short Label hSMC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NTJ3 (SMC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
K4 Methylation PhosphoSitePlus
S22 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 22067460, ...18669648, 19690332, 20068231
S27 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 18669648
S28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 22067460, ...18669648, 19690332
S36 Phosphorylation PhosphoSitePlus
T39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163, 19690332
S41 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 22067460, ...18669648, 19690332, 20068231
T44 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T48 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T85 Phosphorylation PhosphoSitePlus
K93 Methylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K119 Methylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S149 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
C158 Methylation IEDB 31844290
K170 Ubiquitination PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
N193 N-Glycosylation GlyGen 29671580
Y197 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
R214 Methylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
R281 Methylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
K349 Acetylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K354 Acetylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K381 Acetylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K416 Acetylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K573 Acetylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K608 Acetylation PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
K679 Acetylation PhosphoSitePlus   UniProt 19608861
T682 Phosphorylation PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus
T739 Phosphorylation PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
T822 Phosphorylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K898 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K953 Ubiquitination PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
K968 Ubiquitination PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus   UniProt 23186163
K988 Ubiquitination PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
K1009 Acetylation PhosphoSitePlus
K1009 Ubiquitination PhosphoSitePlus
S1013 Phosphorylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
K1031 Acetylation PhosphoSitePlus
K1031 Ubiquitination PhosphoSitePlus
K1037 Acetylation PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
K1041 Ubiquitination PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus
S1056 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 16565220
S1059 Phosphorylation PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
K1097 Ubiquitination PhosphoSitePlus
K1098 Ubiquitination PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
K1112 Ubiquitination PhosphoSitePlus
Y1115 Phosphorylation PhosphoSitePlus
K1145 Ubiquitination PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
Y1266 Phosphorylation PhosphoSitePlus
K1267 Ubiquitination PhosphoSitePlus
K1273 Ubiquitination PhosphoSitePlus
K1280 Ubiquitination PhosphoSitePlus
K1285 Ubiquitination PhosphoSitePlus
C1288 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 18691976, 20230923, 15302935, ...19691289, 18452278, 19651622, 18669648, 19415658, 20068231
S27 Phosphorylation HPRD 18691976, 17081983, 20230923, ...18452278, 19651622, 18669648, 19415658, 20068231
S28 Phosphorylation HPRD 20230923, 15302935, 18452278, ...19651622, 18669648, 19415658, 20068231
S36 Phosphorylation HPRD 19651622, 17081983
T39 Phosphorylation HPRD 19413330, 18691976, 18491316, ...20230923, 20058876, 19664995, 19007248, 19651622, 18452278, 20068231, 19691289
S41 Phosphorylation HPRD 19413330, 17322306, 18491316, ...20230923, 18767875, 20058876, 19664995, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231
T44 Phosphorylation HPRD 18491316, 17081983, 20230923, ...20058876, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231
T48 Phosphorylation HPRD 20058876, 19691289
S50 Phosphorylation HPRD 19413330, 19691289, 18452278
S143 Phosphorylation HPRD 20068231
N193 N-Glycosylation PRO 29671580
S355 Phosphorylation HPRD 19691289
Y616 Phosphorylation HPRD 20068231
S982 Phosphorylation HPRD 19413330, 18452278, 19691289, ...19007248
S1056 Phosphorylation HPRD 16565220, 20068231, 18452278
S1071 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049294 (hSMC4/PhosSer+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T39 M39 Biomuta DOID:263 / kidney cancer [ icgc ]
K106 N106 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K106 E106 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S109 F109 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K119 I119 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S143 T143 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K153 M153 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T188 M188 Biomuta DOID:1324 / lung cancer [ cosmic ]
K202 E202 Biomuta DOID:1324 / lung cancer [ cosmic ]
R214 Q214 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R214 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K389 I389 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K416 N416 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S489 C489 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S531 C531 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K573 E573 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S589 L589 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y616 C616 Biomuta DOID:1324 / lung cancer [ cosmic ]
K857 E857 Biomuta DOID:263 / kidney cancer [ cosmic ]
K922 N922 Biomuta DOID:363 / uterine cancer [ icgc ]
K974 N974 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
K988 E988 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1030 F1030 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1056 L1056 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
K1097 E1097 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1098 M1098 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1145 E1145 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]