Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NTI5 / PDS5B_HUMAN
Protein Name Sister chromatid cohesion protein PDS5 homolog B
Gene Name Name: PDS5B
Synonyms:APRIN,AS3;
Organism Homo sapiens (Human)

PRO ID PR:Q9NTI5
DAG View
PRO Name sister chromatid cohesion protein PDS5 homolog B (human)
Definition A sister chromatid cohesion protein PDS5 homolog B that is encoded in the genome of human.
Short Label hPDS5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NTI5 (PDS5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S140 O-Glycosylation GlyGen 29351928
K212 Acetylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
Y728 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
R802 Methylation PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
Y990 Phosphorylation PhosphoSitePlus
Y1005 Phosphorylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
T1050 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus
K1089 Ubiquitination PhosphoSitePlus
K1103 Acetylation PhosphoSitePlus
K1103 Ubiquitination PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
S1118 Phosphorylation PhosphoSitePlus
T1121 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K1136 Acetylation PhosphoSitePlus   UniProt 19608861
S1139 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S1145 Phosphorylation PhosphoSitePlus
T1147 Phosphorylation PhosphoSitePlus
T1154 Phosphorylation PhosphoSitePlus
S1156 Phosphorylation PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus
S1160 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
S1162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 19690332
S1165 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1166 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...22067460, 24275569, 19690332, 20068231
S1176 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163, 17081983, ...19690332
S1177 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 17081983
S1182 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 22067460, 19690332, 20068231
Y1187 Phosphorylation PhosphoSitePlus
T1188 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 19690332
S1204 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
K1213 Acetylation PhosphoSitePlus
T1220 Phosphorylation PhosphoSitePlus
K1228 Acetylation PhosphoSitePlus
T1235 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus
T1255 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1257 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 22067460, ...18669648, 19690332
S1259 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S1283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...22067460, 19690332, 20068231
T1301 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S1334 Phosphorylation PhosphoSitePlus   UniProt 18669648
K1344 Methylation PhosphoSitePlus
S1349 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 22067460, 15302935, 19367720, 19690332, 20068231
S1361 Phosphorylation PhosphoSitePlus
S1362 Phosphorylation PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus
T1367 Phosphorylation PhosphoSitePlus   UniProt 17525332
S1369 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T1370 Phosphorylation P06493 (CDK1) , P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18847512, ...18234856, 22067460, 19690332
S1379 Phosphorylation PhosphoSitePlus
T1381 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 21406692
S1383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 21406692, 15302935, ...17081983
S1385 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1407 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1416 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1417 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1441 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T1050 Phosphorylation HPRD 19651622
T1121 Phosphorylation HPRD 20068231
S1139 Phosphorylation HPRD 18691976
S1140 Phosphorylation HPRD 20068231
S1160 Phosphorylation HPRD 18691976
S1161 Phosphorylation HPRD 19651622, 18691976
S1162 Phosphorylation HPRD 19413330, 18691976, 19651622
S1165 Phosphorylation HPRD 19413330, 18691976, 19651622, ...20068231
S1166 Phosphorylation HPRD 19413330, 18691976, 15302935, ...19664994, 19664995, 18452278, 19651622, 20068231
S1176 Phosphorylation HPRD 20068231, 18452278
S1177 Phosphorylation HPRD 17081983, 18452278
S1182 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231, 18452278
Y1187 Phosphorylation HPRD 17081983
T1188 Phosphorylation HPRD 17081983, 20068231
S1190 Phosphorylation HPRD 18452278
S1191 Phosphorylation HPRD 18452278
T1235 Phosphorylation HPRD 19664994
T1255 Phosphorylation HPRD 18691976, 17081983, 20068231
S1257 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231, 18452278
S1259 Phosphorylation HPRD 20166139, 18767875, 18669648, ...17081983
S1283 Phosphorylation HPRD 18691976, 18767875, 19664994, ...19664995, 18452278, 19651622, 18669648, 20068231
T1301 Phosphorylation HPRD 18691976
S1319 Phosphorylation HPRD 18669648
S1334 Phosphorylation HPRD 18669648
S1358 Phosphorylation HPRD 19413330, 18691976, 18491316, ...16964243, 18767875, 19664994, 20058876, 19664995, 18452278, 19651622, 15302935, 18707149, 15345747, 20068231, 19691289
S1361 Phosphorylation HPRD 19413330
S1362 Phosphorylation HPRD 16964243
S1366 Phosphorylation HPRD 20068231
T1367 Phosphorylation HPRD 17525332, 18452278
S1369 Phosphorylation HPRD 19651622, 18691976, 19664995, ...20068231, 18452278
T1370 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664995, 18452278, 19651622, 20068231
S1383 Phosphorylation HPRD 15302935, 20068231
S1406 Phosphorylation HPRD 18691976
S1407 Phosphorylation HPRD 18452278
S1417 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S140 L140 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K514 * Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K627 E627 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S628 L628 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K698 E698 Biomuta DOID:363 / uterine cancer [ tcga ]
K717 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R802 Q802 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:4362 / cervical cancer [ tcga ]
R802 W802 Biomuta DOID:363 / uterine cancer [ tcga ]
S1118 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
S1140 L1140 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1159 I1159 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1162 * Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1182 C1182 Biomuta DOID:3571 / liver cancer [ tcga ]
T1188 A1188 Biomuta DOID:2531 / hematologic cancer [ tcga ]
T1188 I1188 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1246 R1246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1255 M1255 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1319 P1319 Biomuta DOID:363 / uterine cancer [ tcga ]
S1361 Y1361 Biomuta DOID:363 / uterine cancer [ tcga ]
T1381 M1381 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ]
S1385 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1416 I1416 Biomuta DOID:3571 / liver cancer [ icgc ]