iPTMnet Report for Q9NTG7 (SIRT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NTG7 / SIR3_HUMAN
Protein Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial precursor
Gene Name Name: SIRT3
Synonyms:SIR2L3;
Organism Homo sapiens (Human)

PRO ID PR:Q9NTG7
DAG View
PRO Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial (human)
Definition An NAD-dependent protein deacetylase sirtuin-3, mitochondrial that is encoded in the genome of human.
Short Label hSIRT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NTG7 (SIRT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R51 Methylation PhosphoSitePlus
R57 Methylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
T150 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26141949
S159 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P 26141949
Y226 Phosphorylation PhosphoSitePlus
R276 Methylation PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
R356 Methylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S101 Phosphorylation HPRD 20068231
S103 Phosphorylation HPRD 20068231
S105 Phosphorylation HPRD 20068231
S114 Phosphorylation HPRD 20068231
S117 Phosphorylation HPRD 20068231
S118 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R51 T51 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S159 L159 Biomuta DOID:3571 / liver cancer [ cosmic ]
R356 H356 Biomuta DOID:9256 / colorectal cancer [ cosmic ]