iPTMnet Report for Q9NSV4 (DIAPH3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NSV4 / DIAP3_HUMAN
Protein Name Protein diaphanous homolog 3
Gene Name Name: DIAPH3
Synonyms:DIAP3;
Organism Homo sapiens (Human)

PRO ID PR:Q9NSV4
DAG View
PRO Name protein diaphanous homolog 3 (human)
Definition A protein diaphanous homolog 3 that is encoded in the genome of human.
Short Label hDIAPH3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NSV4 (DIAPH3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
T19 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S23 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus   UniProt 23186163
R28 Methylation PhosphoSitePlus
R31 Methylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus   UniProt 23186163
K74 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus   UniProt 23186163
K85 Ubiquitination PhosphoSitePlus
K94 Methylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus   UniProt 23186163
C195 Methylation IEDB 31844290
K233 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22593025, 20068231
K653 Methylation PhosphoSitePlus
C663 Methylation IEDB 31844290
K672 Ubiquitination PhosphoSitePlus
Y673 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
K961 Ubiquitination PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
K1032 Ubiquitination PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
S1091 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1096 Phosphorylation PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
K1134 Ubiquitination PhosphoSitePlus
Y1138 Phosphorylation PhosphoSitePlus
S1145 O-Glycosylation GlyGen 31492838, 30059200, 29237092, ...35254053
S1145 Phosphorylation PhosphoSitePlus
S1162 Phosphorylation PhosphoSitePlus
K1166 Ubiquitination PhosphoSitePlus
K1176 Ubiquitination PhosphoSitePlus
S1179 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S361 Phosphorylation HPRD 20068231
T484 Phosphorylation HPRD 17322306
S489 Phosphorylation HPRD 20068231
S570 Phosphorylation HPRD 20068231
S828 Phosphorylation HPRD 19651622, 20068231
S830 Phosphorylation HPRD 20068231
S833 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S624 Phosphorylation HPRD 20068231
T747 Phosphorylation HPRD 17322306
S752 Phosphorylation HPRD 20068231
S833 Phosphorylation HPRD 20068231
S1091 Phosphorylation HPRD 19651622, 20068231
S1093 Phosphorylation HPRD 20068231
S1096 Phosphorylation HPRD 19651622, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K74 R74 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K94 N94 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K115 E115 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S175 L175 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K233 Q233 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K245 R245 Biomuta DOID:4159 / skin cancer [ cosmic ]
S361 F361 Biomuta DOID:4159 / skin cancer [ cosmic ]
K396 R396 Biomuta DOID:363 / uterine cancer [ icgc ]
K532 Q532 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S570 R570 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S570 N570 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S624 F624 Biomuta DOID:4159 / skin cancer [ cosmic ]
K759 N759 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S833 N833 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S833 R833 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S833 Y833 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K912 T912 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K934 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K948 T948 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1096 Y1096 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1134 N1134 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1166 R1166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]