iPTMnet Report Q9NSU2 TREX1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9NSU2 / TREX1_HUMAN
Protein Name	Three-prime repair exonuclease 1
Gene Name	Name: TREX1
Organism	Homo sapiens (Human)

PRO ID	PR:Q9NSU2 DAG View
PRO Name	three-prime repair exonuclease 1 (human)
Definition	A three-prime repair exonuclease 1 that is encoded in the genome of human.
Short Label	hTREX1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9NSU2 (TREX1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S78	Phosphorylation		score2	PhosphoSitePlus UniProt	18669648
	C120	Methylation		score1	IEDB	31844290
	S167	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
	K175	Ubiquitination		score1	PhosphoSitePlus
	S178	Phosphorylation		score1	PhosphoSitePlus
	Y183	Phosphorylation		score1	PhosphoSitePlus
	S261	Phosphorylation		score2	PhosphoSitePlus UniProt	18669648, 23186163
	S263	Phosphorylation		score1	PhosphoSitePlus
	K277	Methylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S78	Phosphorylation		score0	HPRD	18669648
	S167	Phosphorylation		score0	HPRD	17081983
	S261	Phosphorylation		score0	HPRD	18669648, 19007248

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S78	I78	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
K175	N175	Biomuta		DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]