iPTMnet Report for Q9NSK0 (KLC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NSK0 / KLC4_HUMAN
Protein Name Kinesin light chain 4
Gene Name Name: KLC4
Synonyms:KNSL8;
Organism Homo sapiens (Human)

PRO ID PR:Q9NSK0
DAG View
PRO Name kinesin light chain 4 (human)
Definition A kinesin light chain 4 that is encoded in the genome of human.
Short Label hKLC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NSK0 (KLC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378, 22223895
S18 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K391 Acetylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...16964243
T462 Phosphorylation PhosphoSitePlus
T465 Phosphorylation PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
T498 O-Glycosylation GlyGen 31373491
T498 Phosphorylation PhosphoSitePlus
S502 O-Glycosylation GlyGen 31373491
T504 O-Glycosylation GlyGen 31373491
S519 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus   UniProt 23186163
T576 O-Glycosylation GlyGen 23301498, 29485866, 31373491, ...30379171
S590 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 24275569, 19690332, 20068231
Y593 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S605 O-Glycosylation GlyGen 23301498, 29485866, 31373491, ...30379171
S605 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus   UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
S460 Phosphorylation HPRD 17322306, 18691976, 18669648, ...16964243, 20068231
S519 Phosphorylation HPRD 20166139
S566 Phosphorylation HPRD 18212344, 20068231
S590 Phosphorylation HPRD 19413330, 18212344, 20230923, ...20058876, 19664995, 18452278, 18669648, 20166139, 20068231
Y593 Phosphorylation HPRD 19413330
S609 Phosphorylation HPRD 18767875, 20068231
S611 Phosphorylation HPRD 18767875, 20068231
T612 Phosphorylation HPRD 19413330, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S478 Phosphorylation HPRD 17322306, 18691976, 18669648, ...16964243, 20068231
S537 Phosphorylation HPRD 20166139
S584 Phosphorylation HPRD 18212344, 20068231
S608 Phosphorylation HPRD 19413330, 18212344, 20230923, ...20058876, 19664995, 18452278, 18669648, 20166139, 20068231
Y611 Phosphorylation HPRD 19413330
S627 Phosphorylation HPRD 18767875, 20068231
S629 Phosphorylation HPRD 18767875, 20068231
T630 Phosphorylation HPRD 19413330, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S74 F74 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y205 C205 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S459 T459 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T504 M504 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
S542 F542 Biomuta DOID:4159 / skin cancer [ cosmic ]
S542 C542 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S590 F590 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S608 F608 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]