Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NSI6 / BRWD1_HUMAN
Protein Name Bromodomain and WD repeat-containing protein 1
Gene Name Name: BRWD1
Synonyms:C21orf107,WDR9;
Organism Homo sapiens (Human)

PRO ID PR:Q9NSI6
DAG View
PRO Name bromodomain and WD repeat-containing protein 1 (human)
Definition A bromodomain and WD repeat-containing protein 1 that is encoded in the genome of human.
Short Label hBRWD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NSI6 (BRWD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
Y25 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
R382 Methylation PhosphoSitePlus
R388 Methylation PhosphoSitePlus
R393 Methylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S701 Phosphorylation PhosphoSitePlus   UniProt 21406692
S710 Phosphorylation PhosphoSitePlus   UniProt 20068231
S786 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
Y805 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
K1037 Methylation PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
T1275 Phosphorylation PhosphoSitePlus
S1289 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1374 Phosphorylation PhosphoSitePlus
Y1401 Phosphorylation PhosphoSitePlus
S1402 Phosphorylation PhosphoSitePlus
S1464 Phosphorylation PhosphoSitePlus
T1466 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T1477 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S1479 Phosphorylation PhosphoSitePlus   UniProt 20068231
T1480 Phosphorylation PhosphoSitePlus
T1501 Phosphorylation PhosphoSitePlus
S1511 Phosphorylation PhosphoSitePlus
S1512 Phosphorylation PhosphoSitePlus
S1542 Phosphorylation PhosphoSitePlus
S1543 Phosphorylation PhosphoSitePlus
S1605 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S1607 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S1611 Phosphorylation PhosphoSitePlus
S1678 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1683 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1686 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S1703 Phosphorylation PhosphoSitePlus
S1715 Phosphorylation PhosphoSitePlus
S1720 Phosphorylation PhosphoSitePlus
S1755 Phosphorylation PhosphoSitePlus
S1756 Phosphorylation PhosphoSitePlus
S1786 Phosphorylation PhosphoSitePlus
S1788 Phosphorylation PhosphoSitePlus
S1793 Phosphorylation PhosphoSitePlus
S1798 Phosphorylation PhosphoSitePlus
S1811 Phosphorylation PhosphoSitePlus
S1820 Phosphorylation PhosphoSitePlus
S1822 Phosphorylation PhosphoSitePlus
S1825 Phosphorylation PhosphoSitePlus
S1827 Phosphorylation PhosphoSitePlus
S1888 Phosphorylation PhosphoSitePlus
S1904 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1905 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1907 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1910 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1943 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1962 Acetylation PhosphoSitePlus
K1973 Acetylation PhosphoSitePlus
S2003 Phosphorylation PhosphoSitePlus
S2006 Phosphorylation PhosphoSitePlus
S2018 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...19690332
S2020 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...19690332
K2045 Acetylation PhosphoSitePlus
S2046 Phosphorylation PhosphoSitePlus
S2047 Phosphorylation PhosphoSitePlus
S2056 Phosphorylation PhosphoSitePlus
S2058 Phosphorylation PhosphoSitePlus
S2118 Phosphorylation PhosphoSitePlus
S2131 Phosphorylation PhosphoSitePlus
K2139 Ubiquitination PhosphoSitePlus
S2141 Phosphorylation PhosphoSitePlus
S2147 Phosphorylation PhosphoSitePlus
S2157 Phosphorylation PhosphoSitePlus
S2158 Phosphorylation PhosphoSitePlus
S2162 Phosphorylation PhosphoSitePlus
T2164 Phosphorylation PhosphoSitePlus
S2166 Phosphorylation PhosphoSitePlus
K2184 Acetylation PhosphoSitePlus
S2293 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S145 Phosphorylation HPRD 20068231
S418 Phosphorylation HPRD 19007248, 20068231
S696 Phosphorylation HPRD 18669648, 20068231
S701 Phosphorylation HPRD 18669648, 20068231
S710 Phosphorylation HPRD 20068231
S791 Phosphorylation HPRD 18669648, 19007248
T1275 Phosphorylation HPRD 18669648
S1289 Phosphorylation HPRD 18669648
T1366 Phosphorylation HPRD 20068231
S1475 Phosphorylation HPRD 18669648, 19664995, 20068231
T1477 Phosphorylation HPRD 18669648, 19664995, 20068231
S1479 Phosphorylation HPRD 20068231
T1480 Phosphorylation HPRD 18669648
S1605 Phosphorylation HPRD 18669648, 20068231
S1607 Phosphorylation HPRD 18669648, 20068231
S1678 Phosphorylation HPRD 20068231
S1683 Phosphorylation HPRD 20068231
S1686 Phosphorylation HPRD 20068231
S1786 Phosphorylation HPRD 18669648
S1788 Phosphorylation HPRD 18669648
S1793 Phosphorylation HPRD 18669648
S1904 Phosphorylation HPRD 18669648
S1905 Phosphorylation HPRD 18669648
S1907 Phosphorylation HPRD 18669648
S1909 Phosphorylation HPRD 18669648
S1910 Phosphorylation HPRD 18669648
S2018 Phosphorylation HPRD 18669648, 20068231
S2020 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S145 Phosphorylation HPRD 20068231
S418 Phosphorylation HPRD 19007248, 20068231
S696 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S701 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S710 Phosphorylation HPRD 20068231
S791 Phosphorylation HPRD   phospho.ELM 18669648, 19007248
T1275 Phosphorylation HPRD   phospho.ELM 18669648
S1289 Phosphorylation HPRD   phospho.ELM 18669648
T1366 Phosphorylation HPRD 20068231
S1475 Phosphorylation HPRD   phospho.ELM 18669648, 19664995, 20068231
T1477 Phosphorylation HPRD   phospho.ELM 18669648, 19664995, 20068231
S1479 Phosphorylation HPRD 20068231
T1480 Phosphorylation HPRD   phospho.ELM 18669648
S1605 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S1607 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S1678 Phosphorylation HPRD 20068231
S1683 Phosphorylation HPRD 20068231
S1686 Phosphorylation HPRD 20068231
S1786 Phosphorylation HPRD   phospho.ELM 18669648
S1788 Phosphorylation HPRD   phospho.ELM 18669648
S1793 Phosphorylation HPRD   phospho.ELM 18669648
S1904 Phosphorylation HPRD   phospho.ELM 18669648
S1905 Phosphorylation HPRD   phospho.ELM 18669648
S1907 Phosphorylation HPRD   phospho.ELM 18669648
S1909 Phosphorylation HPRD   phospho.ELM 18669648
S1910 Phosphorylation HPRD   phospho.ELM 18669648
S2018 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S2020 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S2214 Phosphorylation HPRD   PhosphoSitePlus 20068231
K2227 Ubiquitination PhosphoSitePlus
Y2249 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K71 T71 Biomuta DOID:363 / uterine cancer [ tcga ]
S102 Y102 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S145 F145 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S228 F228 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R382 W382 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R382 Q382 Biomuta DOID:363 / uterine cancer [ tcga ]
R388 I388 Biomuta DOID:3070 / malignant glioma [ tcga ]
S696 R696 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S696 N696 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S791 L791 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S793 F793 Biomuta DOID:1909 / melanoma [ tcga ]
S840 L840 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1223 C1223 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T1275 K1275 Biomuta DOID:3571 / liver cancer [ icgc ]
S1289 I1289 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S1402 N1402 Biomuta DOID:363 / uterine cancer [ tcga ]
S1511 P1511 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1611 * Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S1720 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1786 N1786 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S1798 T1798 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1798 C1798 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1822 A1822 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1888 A1888 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1904 C1904 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S2006 G2006 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2047 F2047 Biomuta DOID:1909 / melanoma [ tcga ]
S2058 T2058 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S2293 F2293 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]