iPTMnet Report for Q9NSE4 (IARS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NSE4 / SYIM_HUMAN
Protein Name Isoleucine--tRNA ligase, mitochondrial precursor
Gene Name Name: IARS2
Organism Homo sapiens (Human)

PRO ID PR:Q9NSE4
DAG View
PRO Name isoleucine--tRNA ligase, mitochondrial (human)
Definition An isoleucine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hIARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NSE4 (IARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S186 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
K189 Acetylation PhosphoSitePlus   UniProt 19608861
K189 Ubiquitination PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
R225 Methylation PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K233 Acetylation PhosphoSitePlus   UniProt 19608861
Y237 Phosphorylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus   UniProt 19608861
K241 Methylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K455 Sumoylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K479 Acetylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
Y543 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
Y621 Phosphorylation PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
K725 Acetylation PhosphoSitePlus
K775 Acetylation PhosphoSitePlus   UniProt 19608861
K781 Acetylation PhosphoSitePlus   UniProt 19608861
Y798 Phosphorylation PhosphoSitePlus
K803 Acetylation PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
S881 Phosphorylation HPRD   PhosphoSitePlus 20068231
S888 Phosphorylation PhosphoSitePlus
K896 Ubiquitination PhosphoSitePlus
T950 Phosphorylation HPRD   PhosphoSitePlus 20068231
T982 Phosphorylation HPRD 20068231
C1005 S-Nitrosylation dbSNO 26338901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K133 E133 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R225 T225 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K493 N493 Biomuta DOID:263 / kidney cancer [ cosmic ]
K540 N540 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K687 N687 Biomuta DOID:3571 / liver cancer [ cosmic ]
K687 E687 Biomuta DOID:1324 / lung cancer [ cosmic ]
K725 N725 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K781 N781 Biomuta DOID:9256 / colorectal cancer [ cosmic ]