Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NS91 / RAD18_HUMAN
Protein Name E3 ubiquitin-protein ligase RAD18
Gene Name Name: RAD18
Synonyms:RNF73;
Organism Homo sapiens (Human)

PRO ID PR:Q9NS91
DAG View
PRO Name E3 ubiquitin-protein ligase RAD18 (human)
Definition An E3 ubiquitin-protein ligase RAD18 that is encoded in the genome of human.
Short Label hRAD18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NS91 (RAD18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K17 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S99 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...17081983, 18220336, 18767875, 18847512, 15302935, 17322306, 18669648, 19690332, 20068231
K102 Sumoylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S103 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220, 18669648, ...19690332, 20068231
S106 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S107 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S108 Phosphorylation HPRD 20068231
S109 Phosphorylation PhosphoSitePlus
K110 Sumoylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K115 Sumoylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T118 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S122 Phosphorylation PhosphoSitePlus   UniProt 23186163
S125 Phosphorylation PhosphoSitePlus   UniProt 23186163
K127 Sumoylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus   UniProt 23186163
S144 Phosphorylation PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S158 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163
K161 Ubiquitination PhosphoSitePlus
S164 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163
K168 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
K186 Sumoylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K197 Sumoylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K201 Sumoylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K229 Sumoylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
R254 Methylation PhosphoSitePlus
K257 Sumoylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K261 Sumoylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K318 Sumoylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S322 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T327 Phosphorylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K347 Sumoylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Sumoylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K376 Sumoylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S403 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus 17478428, 17525332, 20068231
S409 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 22456510, 19007248, 19691289, ...16565220
S434 Phosphorylation O00311 (CDC7) PhosphoSitePlus   RLIMS-P   Signor 21098111
K462 Ubiquitination PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
S471 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...23186163, 16964243, 15302935, 19664994, 19007248, 19691289, 19651622, 19664995, 18452278, 20068231, 18212344
S483 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K52 T52 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K52 Q52 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K110 N110 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
T118 N118 Biomuta DOID:3571 / liver cancer [ icgc ]
S144 F144 Biomuta DOID:1324 / lung cancer [ tcga ]
S155 R155 Biomuta DOID:363 / uterine cancer [ tcga ]
S174 F174 Biomuta DOID:1909 / melanoma [ tcga ]
K218 T218 Biomuta DOID:1612 / breast cancer [ tcga ]
R254 C254 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K257 N257 Biomuta DOID:363 / uterine cancer [ tcga ]
K341 T341 Biomuta DOID:363 / uterine cancer [ tcga ]
S368 L368 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K376 E376 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]