Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NS56 / TOPRS_HUMAN
Protein Name E3 ubiquitin-protein ligase Topors
Gene Name Name: TOPORS
Synonyms:LUN,TP53BPL;
Organism Homo sapiens (Human)

PRO ID PR:Q9NS56
DAG View
PRO Name E3 ubiquitin-protein ligase Topors (human)
Definition An E3 ubiquitin-protein ligase Topors that is encoded in the genome of human.
Short Label hTOPORS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NS56 (TOPORS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
R28 Methylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K76 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K83 Sumoylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K88 Sumoylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S98 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 15302935, ...18669648, 20068231, 24275569, 19690332, 19053840, 26872363
S101 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S196 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
T205 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K249 Sumoylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus   UniProt 19053840
S501 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
K547 Sumoylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K557 Acetylation PhosphoSitePlus
K559 Acetylation PhosphoSitePlus
K560 Acetylation PhosphoSitePlus
K560 Sumoylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
R572 Methylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
R579 Methylation PhosphoSitePlus
R582 Methylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19053840
Y587 Phosphorylation PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
K701 Sumoylation PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
K711 Sumoylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
S718 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19821153, 19473992, 26872363
S731 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus   UniProt 23186163
S735 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
T784 Phosphorylation PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K799 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
T862 Phosphorylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
S866 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332, 19053840
S902 Phosphorylation phospho.ELM 17081983
S912 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S914 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S918 Phosphorylation phospho.ELM 17081983
S1028 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 20068231
S98 Phosphorylation HPRD 19413330, 18691976, 15302935, ...19664994, 19664995, 18669648, 20068231
S194 Phosphorylation HPRD 18669648, 19007248, 19664995
T205 Phosphorylation HPRD 18669648
S569 Phosphorylation HPRD 20068231
S577 Phosphorylation HPRD 20068231
S585 Phosphorylation HPRD 20068231
S902 Phosphorylation HPRD 17081983
S904 Phosphorylation HPRD 17081983
T909 Phosphorylation HPRD 17081983
S912 Phosphorylation HPRD 17081983, 18452278
S914 Phosphorylation HPRD 17081983, 18452278
S918 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K122 T122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T173 A173 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S194 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S501 F501 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S533 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S567 P567 Biomuta DOID:4362 / cervical cancer [ tcga ]
S567 * Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:2531 / hematologic cancer [ icgc ]
S577 Y577 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y707 * Biomuta DOID:3070 / malignant glioma [ tcga ]
S734 Y734 Biomuta DOID:3571 / liver cancer [ icgc ]
S864 N864 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S904 Y904 Biomuta DOID:1324 / lung cancer [ cosmic ]
S918 F918 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
S918 Y918 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]