Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRZ9 / HELLS_HUMAN
Protein Name Lymphoid-specific helicase
Gene Name Name: HELLS
Synonyms:PASG;ORFNames:Nbla10143;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRZ9
DAG View
PRO Name lymphoid-specific helicase (human)
Definition A lymphoid-specific helicase that is encoded in the genome of human.
Short Label hHELLS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRZ9 (HELLS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K74 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus   UniProt 23186163
S119 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Sumoylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K204 Sumoylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
R309 Methylation PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
K475 Sumoylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 32994405
T505 Phosphorylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
K569 Methylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K753 Methylation PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
R803 Methylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S115 Phosphorylation HPRD 19651622
S188 Phosphorylation HPRD 20068231
T505 Phosphorylation HPRD 18691976, 20068231
S598 Phosphorylation HPRD 20068231
S829 Phosphorylation HPRD 20068231
S832 Phosphorylation HPRD 19413330
S833 Phosphorylation HPRD 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NRZ9 (HELLS) S503 O14744 (PRMT5) unknown eFIP 32994405


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K99 Q99 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K103 N103 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K104 N104 Biomuta DOID:363 / uterine cancer [ tcga ]
K204 R204 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R309 H309 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
T505 A505 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S515 P515 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y651 C651 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K763 N763 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K785 E785 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R803 Q803 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
R803 * Biomuta DOID:363 / uterine cancer [ tcga ]