Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRY4 / RHG35_HUMAN
Protein Name Rho GTPase-activating protein 35
Gene Name Name: ARHGAP35
Synonyms:GRF1;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRY4
DAG View
PRO Name Rho GTPase-activating protein 35 (human)
Definition A Rho GTPase-activating protein 35 that is encoded in the genome of human.
Short Label hARHGAP35
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRY4 (ARHGAP35) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S182 Phosphorylation HPRD 20068231
K193 Acetylation PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19393245, 28007963
K368 Ubiquitination PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S589 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19651622, ...18669648, 24275569, 19690332, 20068231
S591 Phosphorylation HPRD 19651622
S667 Phosphorylation PhosphoSitePlus
T685 Phosphorylation HPRD   phospho.ELM 17081983
K762 Ubiquitination PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus   UniProt 23186163
T771 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
Y855 Phosphorylation PhosphoSitePlus
T906 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
T963 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S970 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S975 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S980 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S985 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S1001 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1004 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
S1070 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S1072 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S1073 Phosphorylation HPRD   phospho.ELM 18669648
S1074 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1085 Phosphorylation PhosphoSitePlus
Y1087 Phosphorylation P06241 (FYN) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32540970, 18083107, 11536198, ...19690332, 16497976
K1096 Ubiquitination PhosphoSitePlus
Y1105 Phosphorylation Q13882 (PTK6) , P12931 (SRC) , P42684 (ABL2) , P06241 (FYN) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17016520, 11536198, 15084284, ...9819392, 18083107, 30166526, 18829532, 19901323, 11309200, 15592455, 19690332, 20068231, 16497976
S1106 Phosphorylation PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus
T1112 Phosphorylation PhosphoSitePlus
K1115 Ubiquitination PhosphoSitePlus
S1127 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1130 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18452278, 19651622, 19690332
S1136 Phosphorylation PhosphoSitePlus
T1140 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1141 Phosphorylation HPRD   phospho.ELM 18669648
S1142 Phosphorylation PhosphoSitePlus
S1150 Phosphorylation Q13464 (ROCK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 16083285, 23186163, ...18767875, 19651622, 18669648, 24275569, 19103606, 20068231
S1153 Phosphorylation PhosphoSitePlus
Y1158 Phosphorylation HPRD   PhosphoSitePlus 19651622
T1173 Phosphorylation Q13464 (ROCK1) HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19103606
S1174 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus 19103606
S1176 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1179 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...23186163, 18220336, 18767875, 20230923, 19664994, 18578522, 19664995, 19651622, 15302935, 18669648, 19415658, 24275569, 18088087, 18452278, 19690332, 20068231, 20058876
S1195 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
Y1198 Phosphorylation PhosphoSitePlus
Y1207 Phosphorylation PhosphoSitePlus
T1209 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   UniProt 19673492
T1226 Phosphorylation Q13464 (ROCK1) , P17252 (PRKCA) PhosphoSitePlus   UniProt 19673492, 19103606
S1236 Phosphorylation Q13464 (ROCK1) , P17252 (PRKCA) PhosphoSitePlus   Signor   UniProt 19673492, 19103606
K1289 Ubiquitination PhosphoSitePlus
S1290 Phosphorylation PhosphoSitePlus
K1353 Ubiquitination PhosphoSitePlus
K1358 Ubiquitination PhosphoSitePlus
K1381 Ubiquitination PhosphoSitePlus
S1450 Phosphorylation HPRD 20068231
S1476 Phosphorylation HPRD 20068231
T1480 Phosphorylation HPRD 20068231
S1491 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046380 (hARHGAP35/Phos:1) pY1105 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K193 T193 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y308 C308 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K368 Q368 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K368 * Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S575 I575 Biomuta DOID:3571 / liver cancer [ icgc ]
S589 * Biomuta DOID:363 / uterine cancer [ tcga ]
T685 M685 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K762 R762 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S769 I769 Biomuta DOID:3571 / liver cancer [ icgc ]
S962 N962 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S962 T962 Biomuta DOID:1324 / lung cancer [ tcga ]
S975 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S980 L980 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S985 * Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S1001 * Biomuta DOID:1324 / lung cancer [ tcga ]
Y1105 C1105 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1106 F1106 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1111 G1111 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1127 A1127 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1141 N1141 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1153 I1153 Biomuta DOID:3571 / liver cancer [ icgc ]
S1176 N1176 Biomuta DOID:363 / uterine cancer [ tcga ]
S1290 Y1290 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K1358 T1358 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1480 P1480 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
S1491 F1491 Biomuta DOID:1909 / melanoma [ icgc, tcga ]