Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NRM7 / LATS2_HUMAN
Protein Name Serine/threonine-protein kinase LATS2
Gene Name Name: LATS2
Organism Homo sapiens (Human)

DAG View
PRO Name serine/threonine-protein kinase LATS2 (human)
Definition A serine/threonine-protein kinase LATS2 that is encoded in the genome of human.
Short Label hLATS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NRM7 (LATS2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation O14965 (AURKA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15147269, 26732741, 22904328, ...21822051
Y135 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T168 O-Glycosylation PhosphoSitePlus
T168 Phosphorylation RLIMS-P 32513743
S172 Phosphorylation O14757 (CHEK1) , O96017 (CHEK2) neXtProt   PhosphoSitePlus 21118956, 23886938
S274 Phosphorylation PhosphoSitePlus
S277 O-Glycosylation GlyGen 29351928
K278 Ubiquitination PhosphoSitePlus
T279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y286 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S380 Phosphorylation O96017 (CHEK2) , O14965 (AURKA) , O14757 (CHEK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 21118956, 23886938, ...21822051, 15147269, 18669648
S408 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) neXtProt   PhosphoSitePlus 21118956, 23886938
T436 O-Glycosylation PhosphoSitePlus
T436 Phosphorylation RLIMS-P 32513743
S446 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) neXtProt   PhosphoSitePlus 21118956, 23886938
S528 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
K565 Acetylation PhosphoSitePlus
K570 Acetylation PhosphoSitePlus
K571 Acetylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus   UniProt 23186163
S598 Phosphorylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
T690 Phosphorylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
S829 Phosphorylation HPRD 12853976
S835 Phosphorylation O14757 (CHEK1) , Q9NRM7 (LATS2) neXtProt   PhosphoSitePlus   RLIMS-P 10871863, 21118956, 23886938
S872 Phosphorylation Q13043 (STK4) , Q13188 (STK3) PhosphoSitePlus   RLIMS-P   Signor 26898830, 32513743, 23431053, ...21808241, 21832154
K939 Ubiquitination PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
K968 Ubiquitination PhosphoSitePlus
K984 Ubiquitination PhosphoSitePlus
T1024 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1026 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1027 Phosphorylation PhosphoSitePlus
Y1038 Phosphorylation PhosphoSitePlus
T1041 Phosphorylation Q13188 (STK3) , Q13043 (STK4) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 31669263, 32513743, 23431053, ...21808241, 30154411, 21832154, 21952048, 26898830
Y1051 Phosphorylation PhosphoSitePlus

Q9NRM7 (LATS2) as PTM Enzyme

Substrate Site Score Source PMID
O95863 (SNAI1) T203 neXtProt   PhosphoSitePlus   Signor 21952048
P00519-2 (ABL1) T197 PhosphoSitePlus 23852372
P38936 (CDKN1A) S146 neXtProt   PhosphoSitePlus 23886938
P46937 (YAP1) S127 neXtProt   PhosphoSitePlus   Signor 18565851, 22863277, 18640976, ...22658639, 21832154, 21909427, 18369314, 20153295, 21233212, 25362852
P46937 (YAP1) S397 Signor 20048001
P61981 (YWHAG) S59 PhosphoSitePlus   Signor 21118956, 25086053
Q02241 (KIF23) S716 PhosphoSitePlus 25786116
Q02241 (KIF23) S814 PhosphoSitePlus 25786116
Q4VCS5 (AMOT) S175 PhosphoSitePlus 24106267, 24225952
Q8NHZ8 (CDC26) T7 PhosphoSitePlus 25723520
Q9GZV5 (WWTR1) S89 neXtProt   Signor 21808241, 22658639, 18227151
Q9NQS7 (INCENP) S894 RLIMS-P+ 27512725
Q9NRM7 (LATS2) S835 neXtProt 10871863, 23886938
Q9Y2J4 (AMOTL2) S159 PhosphoSitePlus 24225952

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95863 (SNAI1) T203 Q9NRM7 (LATS2) unknown eFIP 21952048
Phosphorylation P35240 (NF2) S518 Q9NRM7 (LATS2) unknown eFIP 33368671
Phosphorylation Q9NRM7 (LATS2) T1041 P02545 (LMNA) unknown eFIP 21952048
Phosphorylation Q9NRM7 (LATS2) T1041 O95863 (SNAI1) unknown eFIP 21952048

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 K9 Biomuta DOID:3571 / liver cancer [ icgc ]
T168 K168 Biomuta DOID:3571 / liver cancer [ icgc ]
T168 M168 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S528 L528 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K697 * Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S835 R835 Biomuta DOID:3571 / liver cancer [ icgc ]
S872 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T1041 P1041 Biomuta DOID:1612 / breast cancer [ icgc ]
T1041 A1041 Biomuta DOID:363 / uterine cancer [ tcga ]