iPTMnet Report for Q9NRG4 (SMYD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRG4 / SMYD2_HUMAN
Protein Name N-lysine methyltransferase SMYD2
Gene Name Name: SMYD2
Synonyms:KMT3C;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRG4
DAG View
PRO Name N-lysine methyltransferase SMYD2 (human)
Definition An N-lysine methyltransferase SMYD2 that is encoded in the genome of human.
Short Label hSMYD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRG4 (SMYD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus   UniProt 23186163
K312 Ubiquitination PhosphoSitePlus
K398 Methylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T44 K44 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T44 A44 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K127 T127 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K145 N145 Biomuta DOID:1324 / lung cancer [ cosmic ]
K427 E427 Biomuta DOID:9256 / colorectal cancer [ cosmic ]