iPTMnet Report for Q9NRF9 (POLE3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRF9 / DPOE3_HUMAN
Protein Name DNA polymerase epsilon subunit 3
Gene Name Name: POLE3
Synonyms:CHRAC17;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRF9
DAG View
PRO Name DNA polymerase epsilon subunit 3 (human)
Definition A DNA polymerase epsilon subunit 3 that is encoded in the genome of human.
Short Label hPOLE3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRF9 (POLE3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K20 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
T63 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S67 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
T83 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K86 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S116 Phosphorylation HPRD   phospho.ELM 18669648
S122 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17081983, ...19651622, 18669648, 20068231
R123 Methylation PhosphoSitePlus
R133 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ icgc ]
T63 M63 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S67 G67 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S116 L116 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S116 * Biomuta DOID:363 / uterine cancer [ cosmic ]