iPTMnet Report for Q9NRF8 (CTPS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRF8 / PYRG2_HUMAN
Protein Name CTP synthase 2
Gene Name Name: CTPS2
Organism Homo sapiens (Human)

PRO ID PR:Q9NRF8
DAG View
PRO Name CTP synthase 2 (human)
Definition A CTP synthase 2 that is encoded in the genome of human.
Short Label hCTPS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRF8 (CTPS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K169 Methylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
R205 Methylation PhosphoSitePlus
C243 Methylation IEDB 31844290
S261 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus
R389 Methylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S563 Phosphorylation HPRD   phospho.ELM 18669648
S564 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
R566 Methylation PhosphoSitePlus
Y567 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20166139
S568 Phosphorylation P48729 (CSNK1A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 21406692, 23186163, ...20739275, 18452278, 19651622, 18669648, 24275569, 20166139, 19415658, 20068231
S571 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 23186163, ...20739275, 18452278, 19651622, 18669648, 24275569, 20166139, 19415658, 20068231, 17081983
S574 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18452278, ...19651622, 18669648, 24275569, 19415658, 20068231
S576 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 * Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S12 L12 Biomuta DOID:363 / uterine cancer [ icgc ]
K92 N92 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T189 I189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K353 T353 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S562 P562 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S564 G564 Biomuta DOID:1324 / lung cancer [ cosmic ]
R566 * Biomuta DOID:1324 / lung cancer [ tcga ]
S574 R574 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S576 L576 Biomuta DOID:4159 / skin cancer [ cosmic ]