iPTMnet Report for Q9NRF2 (SH2B1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRF2 / SH2B1_HUMAN
Protein Name SH2B adapter protein 1
Gene Name Name: SH2B1
Synonyms:KIAA1299,SH2B;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRF2
DAG View
PRO Name SH2B adapter protein 1 (human)
Definition An SH2B adapter protein 1 that is encoded in the genome of human.
Short Label hSH2B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRF2 (SH2B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y48 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S96 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   UniProt 18669648, 10473609, 18220336
S102 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S161 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 21878491
S165 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 21878491
R211 Methylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
R235 Methylation PhosphoSitePlus
R270 Methylation PhosphoSitePlus   UniProt 24129315
K289 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
Y624 Phosphorylation PhosphoSitePlus
Y753 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation HPRD 18669648
S96 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S51 C51 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S65 F65 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S102 L102 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S154 F154 Biomuta DOID:4159 / skin cancer [ cosmic ]
S161 F161 Biomuta DOID:4159 / skin cancer [ cosmic ]
S165 L165 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R211 K211 Biomuta DOID:4159 / skin cancer [ cosmic ]
R235 Q235 Biomuta DOID:363 / uterine cancer [ icgc ]
R235 W235 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R270 W270 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S352 F352 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S580 L580 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]