iPTMnet Report for Q9NRE2 (TSHZ2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRE2 / TSH2_HUMAN
Protein Name Teashirt homolog 2
Gene Name Name: TSHZ2
Synonyms:C20orf17,TSH2,ZNF218;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRE2
DAG View
PRO Name teashirt homolog 2 (human)
Definition A teashirt homolog 2 that is encoded in the genome of human.
Short Label hTSHZ2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRE2 (TSHZ2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Sumoylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
K461 Sumoylation PhosphoSitePlus
K480 Sumoylation PhosphoSitePlus
K601 Sumoylation PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
K644 Acetylation PhosphoSitePlus
K645 Acetylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
K800 Sumoylation PhosphoSitePlus
K820 Sumoylation PhosphoSitePlus
S897 Phosphorylation PhosphoSitePlus
S980 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 N28 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K28 Q28 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S72 N72 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K302 N302 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S440 Y440 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K601 T601 Biomuta DOID:1612 / breast cancer [ cosmic ]
K601 N601 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
T639 A639 Biomuta DOID:1909 / melanoma [ cosmic ]