Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NRC8 / SIR7_HUMAN
Protein Name NAD-dependent protein deacetylase sirtuin-7
Gene Name Name: SIRT7
Organism Homo sapiens (Human)

DAG View
PRO Name NAD-dependent protein deacetylase sirtuin-7 (human)
Definition An NAD-dependent protein deacetylase sirtuin-7 that is encoded in the genome of human.
Short Label hSIRT7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NRC8 (SIRT7) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R11 Methylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
R388 Methylation PhosphoSitePlus   UniProt 24129315

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R11 C11 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K131 N131 Biomuta DOID:3070 / malignant glioma [ cosmic ]
S359 W359 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S359 L359 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]