iPTMnet Report for Q9NR97 (TLR8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR97 / TLR8_HUMAN
Protein Name Toll-like receptor 8 precursor
Gene Name Name: TLR8
ORFNames:UNQ249/PRO286;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR97
DAG View
PRO Name Toll-like receptor 8 (human)
Definition A Toll-like receptor 8 that is encoded in the genome of human.
Short Label hTLR8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR97 (TLR8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N80 N-Glycosylation GlyGen   UniProt 19159218
N88 N-Glycosylation GlyGen   UniProt 19159218
N247 N-Glycosylation GlyGen 24190977
N285 N-Glycosylation GlyGen 24190977
N293 N-Glycosylation GlyGen   UniProt 23520111, 24190977
N303 N-Glycosylation GlyGen 24190977
S345 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
N395 N-Glycosylation GlyGen   UniProt 23520111
N443 N-Glycosylation GlyGen 24190977
N511 N-Glycosylation GlyGen   UniProt 23520111
N546 N-Glycosylation GlyGen   UniProt 23520111
N582 N-Glycosylation GlyGen 24190977
N590 N-Glycosylation GlyGen   UniProt 23520111, 24190977
N640 N-Glycosylation GlyGen   UniProt 23520111
N680 N-Glycosylation GlyGen   UniProt 23520111
T762 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Y880 Phosphorylation PhosphoSitePlus
Y886 Phosphorylation PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
Y1030 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N247 D247 Biomuta DOID:3571 / liver cancer [ cosmic ]
N247 H247 Biomuta DOID:363 / uterine cancer [ icgc ]
N303 K303 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y348 C348 Biomuta DOID:363 / uterine cancer [ icgc ]
N640 T640 Biomuta DOID:9256 / colorectal cancer [ cosmic, tcga ]
S765 Y765 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]