iPTMnet Report for Q9NR81 (ARHGEF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR81 / ARHG3_HUMAN
Protein Name Rho guanine nucleotide exchange factor 3
Gene Name Name: ARHGEF3
Organism Homo sapiens (Human)

PRO ID PR:Q9NR81
DAG View
PRO Name Rho guanine nucleotide exchange factor 3 (human)
Definition A Rho guanine nucleotide exchange factor 3 that is encoded in the genome of human.
Short Label hARHGEF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR81 (ARHGEF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S47 Phosphorylation IEDB   PhosphoSitePlus   UniProt 30784271, 23186163
K56 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
C371 Methylation IEDB 31844290
K382 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 L47 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S79 L79 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
K325 R325 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S399 F399 Biomuta DOID:4159 / skin cancer [ cosmic ]