iPTMnet Report for Q9NR80 (ARHGEF4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR80 / ARHG4_HUMAN
Protein Name Rho guanine nucleotide exchange factor 4
Gene Name Name: ARHGEF4
Synonyms:KIAA1112;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR80
DAG View
PRO Name Rho guanine nucleotide exchange factor 4 (human)
Definition A Rho guanine nucleotide exchange factor 4 that is encoded in the genome of human.
Short Label hARHGEF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR80 (ARHGEF4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation P12931 (SRC) Signor 18653540
S279 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y94 Phosphorylation P12931 (SRC) PhosphoSitePlus 18653540
Y104 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T644 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y94 F94 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S109 P109 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S112 Y112 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y165 F165 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S279 N279 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T286 A286 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]