iPTMnet Report for Q9NR50 (EIF2B3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR50 / EI2BG_HUMAN
Protein Name Translation initiation factor eIF-2B subunit gamma
Gene Name Name: EIF2B3
Organism Homo sapiens (Human)

PRO ID PR:Q9NR50
DAG View
PRO Name translation initiation factor eIF-2B subunit gamma (human)
Definition A translation initiation factor eIF-2B subunit gamma that is encoded in the genome of human.
Short Label hEIF2B3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR50 (EIF2B3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
K61 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K134 Methylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K148 Methylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
C310 Methylation IEDB 31844290
S314 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
C390 Methylation IEDB 31844290
K422 Ubiquitination PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K146 T146 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K146 R146 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K148 T148 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K148 E148 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
Y264 C264 Biomuta DOID:1319 / brain cancer [ cosmic ]