Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR48 / ASH1L_HUMAN
Protein Name Histone-lysine N-methyltransferase ASH1L
Gene Name Name: ASH1L
Synonyms:KIAA1420,KMT2H;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR48
DAG View
PRO Name histone-lysine N-methyltransferase ASH1L (human)
Definition A histone-lysine N-methyltransferase ASH1L that is encoded in the genome of human.
Short Label hASH1L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR48 (ASH1L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S22 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T78 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K358 Acetylation PhosphoSitePlus
K375 Acetylation UniProt 19413330
K375 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K406 Acetylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K474 Methylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
K480 Methylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
K834 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
K902 Acetylation PhosphoSitePlus
K904 Acetylation PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
K996 Ubiquitination PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus
K1041 Ubiquitination PhosphoSitePlus
K1042 Acetylation PhosphoSitePlus
S1162 Phosphorylation PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus
Q1220 Methylation UniProt 26797129
S1226 Phosphorylation PhosphoSitePlus
K1251 Acetylation PhosphoSitePlus
K1253 Acetylation PhosphoSitePlus
K1438 Ubiquitination PhosphoSitePlus
K1441 Ubiquitination PhosphoSitePlus
T1454 Phosphorylation PhosphoSitePlus
T1455 Phosphorylation PhosphoSitePlus
R1508 Methylation PhosphoSitePlus
R1516 Methylation PhosphoSitePlus
K1521 Ubiquitination PhosphoSitePlus
S1539 Phosphorylation PhosphoSitePlus
S1544 Phosphorylation PhosphoSitePlus
S1546 Phosphorylation PhosphoSitePlus
K1626 Ubiquitination PhosphoSitePlus
S1630 Phosphorylation PhosphoSitePlus
T1639 Phosphorylation PhosphoSitePlus
S1640 Phosphorylation PhosphoSitePlus
S1649 Phosphorylation PhosphoSitePlus
S1667 Phosphorylation PhosphoSitePlus
T1678 Phosphorylation PhosphoSitePlus
S1681 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T1683 Phosphorylation PhosphoSitePlus
S1689 Phosphorylation PhosphoSitePlus
S1701 Phosphorylation PhosphoSitePlus
S1703 Phosphorylation PhosphoSitePlus
S1709 Phosphorylation PhosphoSitePlus
S1713 Phosphorylation PhosphoSitePlus
S1716 Phosphorylation PhosphoSitePlus
S1747 Phosphorylation PhosphoSitePlus
S1748 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1754 Phosphorylation PhosphoSitePlus
S1791 Phosphorylation PhosphoSitePlus
K1828 Ubiquitination PhosphoSitePlus
K1917 Ubiquitination PhosphoSitePlus
S1943 Phosphorylation PhosphoSitePlus
Y1989 Phosphorylation PhosphoSitePlus
Y1995 Phosphorylation PhosphoSitePlus
Y1999 Phosphorylation PhosphoSitePlus
K2000 Ubiquitination PhosphoSitePlus
K2086 Ubiquitination PhosphoSitePlus
K2287 Ubiquitination PhosphoSitePlus
T2339 Phosphorylation PhosphoSitePlus
T2427 Phosphorylation PhosphoSitePlus
K2460 Ubiquitination PhosphoSitePlus
K2486 Ubiquitination PhosphoSitePlus
T2507 Phosphorylation PhosphoSitePlus
K2517 Ubiquitination PhosphoSitePlus
K2706 Ubiquitination PhosphoSitePlus
K2776 Ubiquitination PhosphoSitePlus
Y2781 Phosphorylation PhosphoSitePlus
Y2785 Phosphorylation PhosphoSitePlus
Y2802 Phosphorylation PhosphoSitePlus
Y2809 Phosphorylation PhosphoSitePlus
K2822 Ubiquitination PhosphoSitePlus
S2825 Phosphorylation PhosphoSitePlus
S2904 Phosphorylation PhosphoSitePlus
T2912 Phosphorylation PhosphoSitePlus
S2951 Phosphorylation PhosphoSitePlus
T2959 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 18669648
T78 Phosphorylation HPRD 19664994
S230 Phosphorylation HPRD 19413330
S557 Phosphorylation HPRD 20068231
S918 Phosphorylation HPRD 20068231
S920 Phosphorylation HPRD 20068231
S1162 Phosphorylation HPRD 20068231
S1170 Phosphorylation HPRD 20068231
S1649 Phosphorylation HPRD 19007248
S1748 Phosphorylation HPRD 18669648
Y2797 Phosphorylation HPRD 18452278
Y2804 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 I22 Biomuta DOID:363 / uterine cancer [ tcga ]
K176 N176 Biomuta DOID:3070 / malignant glioma [ tcga ]
T226 I226 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T226 N226 Biomuta DOID:3571 / liver cancer [ icgc ]
T244 N244 Biomuta DOID:3571 / liver cancer [ icgc ]
K375 N375 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K467 N467 Biomuta DOID:363 / uterine cancer [ tcga ]
S789 Y789 Biomuta DOID:1324 / lung cancer [ tcga ]
S800 C800 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1008 P1008 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1031 C1031 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1170 C1170 Biomuta DOID:1612 / breast cancer [ tcga ]
S1226 Y1226 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T1454 I1454 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R1516 P1516 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
R1516 S1516 Biomuta DOID:3571 / liver cancer [ icgc ]
R1516 H1516 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:1324 / lung cancer [ tcga ]
R1516 C1516 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1630 R1630 Biomuta DOID:3571 / liver cancer [ icgc ]
S1667 P1667 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1681 R1681 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1681 N1681 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K2086 E2086 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y2809 N2809 Biomuta DOID:1909 / melanoma [ cosmic ]
K2822 R2822 Biomuta DOID:1909 / melanoma [ cosmic ]
S2904 I2904 Biomuta DOID:1612 / breast cancer [ tcga ]
T2959 N2959 Biomuta DOID:3571 / liver cancer [ icgc ]