iPTMnet Report for Q9NR46 (SH3GLB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR46 / SHLB2_HUMAN
Protein Name Endophilin-B2
Gene Name Name: SH3GLB2
Synonyms:KIAA1848;ORFNames:PP578;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR46
DAG View
PRO Name endophilin-B2 (human)
Definition An endophilin-B2 that is encoded in the genome of human.
Short Label hSH3GLB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR46 (SH3GLB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K6 Methylation PhosphoSitePlus
K7 Methylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus   UniProt 23186163
K26 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
R196 Methylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
R230 Methylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K50 N50 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K55 N55 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K79 N79 Biomuta DOID:4159 / skin cancer [ cosmic ]
K178 N178 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T188 M188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T188 A188 Biomuta DOID:1319 / brain cancer [ cosmic ]
R198 C198 Biomuta DOID:3571 / liver cancer [ cosmic ]
R198 L198 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S205 G205 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S207 F207 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y263 C263 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]