iPTMnet Report for Q9NR30 (DDX21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR30 / DDX21_HUMAN
Protein Name Nucleolar RNA helicase 2
Gene Name Name: DDX21
Organism Homo sapiens (Human)

PRO ID PR:Q9NR30
DAG View
PRO Name nucleolar RNA helicase 2 (human)
Definition A nucleolar RNA helicase 2 that is encoded in the genome of human.
Short Label hDDX21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR30 (DDX21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S7 Phosphorylation PhosphoSitePlus   UniProt 23186163
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T15 Phosphorylation PhosphoSitePlus
K18 Acetylation PhosphoSitePlus   UniProt 28790157
K19 Acetylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S71 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...16565220, 18669648, 23186163, 20068231
K73 Ubiquitination PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S89 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...32522876, 34725712, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 32119511, 28510447, 22121020, 33465208
S89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18669648, 17287340, 20068231, 17924679
K91 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Sumoylation PhosphoSitePlus
S121 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 16565220, 18669648, 17287340, 19690332, 20068231
K129 Acetylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K137 Acetylation PhosphoSitePlus   UniProt 28790157
S147 Phosphorylation PhosphoSitePlus
S164 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S168 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S171 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...32522876, 34725712, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 32119511, 28510447, 22121020, 33465208
S171 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 18220336
S173 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K184 Ubiquitination PhosphoSitePlus
K199 Sumoylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S239 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...32522876, 34725712, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 32119511, 28510447, 22121020, 33465208
R255 Methylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R306 Methylation PhosphoSitePlus
T315 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K327 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
R432 Methylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K481 Methylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
Y521 Phosphorylation PhosphoSitePlus
C539 Methylation IEDB 31844290
Y541 Phosphorylation PhosphoSitePlus
Y547 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
S567 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T569 Phosphorylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K577 Acetylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
K600 Acetylation PhosphoSitePlus   UniProt 28790157
S628 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
K668 Sumoylation PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
C682 Methylation IEDB 31844290
Y721 Phosphorylation PhosphoSitePlus
R725 Methylation PhosphoSitePlus
R728 Methylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
S759 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...32522876, 34725712, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 32119511, 28510447, 22121020, 33465208
S759 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
K779 Acetylation PhosphoSitePlus   UniProt 19608861
K779 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
S71 Phosphorylation HPRD 17287340, 18767875, 19664994, ...19007248, 18452278, 19651622, 18669648, 16565220, 19415658, 20068231, 19691289
S89 Phosphorylation HPRD 19413330, 17287340, 16565220, ...18767875, 19664994, 19664995, 19691289, 19651622, 18669648, 18707149, 19007248, 18452278, 17924679, 19415658, 20068231, 20068230
S121 Phosphorylation HPRD 19413330, 17287340, 18212344, ...19562805, 18767875, 16565220, 19664995, 19007248, 19651622, 18669648, 18707149, 20166139, 18452278, 19415658, 20068231, 19691289
S164 Phosphorylation HPRD 18669648, 18452278
S168 Phosphorylation HPRD 19413330, 18669648, 18452278
S171 Phosphorylation HPRD 19413330, 18669648, 15302935, ...18452278
S173 Phosphorylation HPRD 19413330, 18669648, 18452278
T296 Phosphorylation HPRD 20068231
T315 Phosphorylation HPRD 18669648, 19691289, 20068231
S358 Phosphorylation HPRD 18452278
Y361 Phosphorylation HPRD 18452278
S466 Phosphorylation HPRD 20068231
S513 Phosphorylation HPRD 20068231
S567 Phosphorylation HPRD 18669648, 19691289, 20068231
T569 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 Y71 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K73 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K137 Q137 Biomuta DOID:363 / uterine cancer [ icgc ]
R255 M255 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K387 N387 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K403 N403 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R432 Q432 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K474 R474 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K573 Q573 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K577 N577 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K595 R595 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S632 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R728 Q728 Biomuta DOID:10534 / stomach cancer [ cosmic ]