iPTMnet Report for Q9NR28 (DIABLO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR28 / DBLOH_HUMAN
Protein Name Diablo IAP-binding mitochondrial protein precursor
Gene Name Name: DIABLO
Synonyms:SMAC;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR28
DAG View
PRO Name diablo IAP-binding mitochondrial protein (human)
Definition A diablo IAP-binding mitochondrial protein that is encoded in the genome of human.
Short Label hDIABLO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR28 (DIABLO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation P45983 (MAPK8) PhosphoSitePlus   RLIMS-P 25310587
S9 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 25310587
S11 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S67 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 26458825, 24038446
K123 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036235 (hDIABLO/Ac:1) acM1 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NR28 (DIABLO) S67 P98170 (XIAP) increased_association eFIP 24038446


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q9NR28-1 (hDIABLO/iso:1) Interaction PR:O15392 (hBIRC5) PRO 12660240
PR:Q9NR28-1 (hDIABLO/iso:1) Interaction PR:P98170 (hXIAP) PRO 12660240


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S230 P230 Biomuta DOID:363 / uterine cancer [ cosmic ]