Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR22 / ANM8_HUMAN
Protein Name Protein arginine N-methyltransferase 8
Gene Name Name: PRMT8
Synonyms:HRMT1L3,HRMT1L4;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR22
DAG View
PRO Name protein arginine N-methyltransferase 8 (human)
Definition A protein arginine N-methyltransferase 8 that is encoded in the genome of human.
Short Label hPRMT8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR22 (PRMT8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 16051612, 26876602
K15 Ubiquitination PhosphoSitePlus
R58 Methylation Q9NR22 (PRMT8) PhosphoSitePlus   UniProt 17925405
R73 Methylation Q9NR22 (PRMT8) PhosphoSitePlus   UniProt 17925405
S126 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T122 Phosphorylation HPRD 20068231
S126 Phosphorylation HPRD 20068231


Q9NR22 (PRMT8) as PTM Enzyme



Substrate Site Score Source PMID
Q9NR22 (PRMT8) R58 UniProt 17925405
Q9NR22 (PRMT8) R73 UniProt 17925405


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R58 W58 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R73 I73 Biomuta DOID:363 / uterine cancer [ tcga ]
T122 I122 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S126 Y126 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S126 F126 Biomuta DOID:1324 / lung cancer [ cosmic ]
K168 N168 Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y193 C193 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y193 F193 Biomuta DOID:363 / uterine cancer [ tcga ]
Y222 * Biomuta DOID:1324 / lung cancer [ cosmic ]