iPTMnet Report Q9NR22 PRMT8

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9NR22 / ANM8_HUMAN
Protein Name	Protein arginine N-methyltransferase 8
Gene Name	Name: PRMT8 Synonyms:HRMT1L3,HRMT1L4;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9NR22 DAG View
PRO Name	protein arginine N-methyltransferase 8 (human)
Definition	A protein arginine N-methyltransferase 8 that is encoded in the genome of human.
Short Label	hPRMT8
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9NR22 (PRMT8) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	G2	Myristoylation		score3	UniProt	16051612, 26876602
	K15	Ubiquitination		score1	PhosphoSitePlus
	R58	Methylation	Q9NR22 (PRMT8)	score3	PhosphoSitePlus UniProt	17925405
	R73	Methylation	Q9NR22 (PRMT8)	score3	PhosphoSitePlus UniProt	17925405
	S126	Phosphorylation		score1	PhosphoSitePlus
	K168	Acetylation		score1	PhosphoSitePlus
	K168	Ubiquitination		score1	PhosphoSitePlus
	Y189	Phosphorylation		score1	PhosphoSitePlus
	Y193	Phosphorylation		score1	PhosphoSitePlus
	Y222	Phosphorylation		score1	PhosphoSitePlus
	Y281	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T122	Phosphorylation		score0	HPRD	20068231
	S126	Phosphorylation		score0	HPRD	20068231

Q9NR22 (PRMT8) as PTM Enzyme

Protein as Methylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q9NR22 (PRMT8)	R58	score2	UniProt	17925405
	Q9NR22 (PRMT8)	R73	score2	UniProt	17925405

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
R58	W58	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R73	I73	Biomuta		DOID:363 / uterine cancer [ icgc ]
R73	K73	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T122	I122	Biomuta		DOID:5041 / esophageal cancer [ cosmic, icgc ]
S126	Y126	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S126	F126	Biomuta		DOID:1324 / lung cancer [ cosmic ]
K168	N168	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
Y193	C193	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
Y222	*	Biomuta		DOID:1324 / lung cancer [ cosmic ]
Y281	C281	Biomuta		DOID:1324 / lung cancer [ cosmic ]