iPTMnet Report Q9NR20 DYRK4

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9NR20 / DYRK4_HUMAN
Protein Name	Dual specificity tyrosine-phosphorylation-regulated kinase 4
Gene Name	Name: DYRK4
Organism	Homo sapiens (Human)

PRO ID	PR:Q9NR20 DAG View
PRO Name	dual specificity tyrosine-phosphorylation-regulated kinase 4 (human)
Definition	A dual specificity tyrosine-phosphorylation-regulated kinase 4 that is encoded in the genome of human.
Short Label	hDYRK4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9NR20 (DYRK4) as Substrate

Q9NR20

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T37	Phosphorylation		score1	PhosphoSitePlus
	K71	Ubiquitination		score1	PhosphoSitePlus
	K72	Ubiquitination		score1	PhosphoSitePlus
	T211	Phosphorylation		score1	PhosphoSitePlus
	S213	Phosphorylation		score1	PhosphoSitePlus
	S222	Phosphorylation		score1	PhosphoSitePlus
	Y262	Phosphorylation		score1	PhosphoSitePlus
	T263	Phosphorylation		score1	PhosphoSitePlus
	Y264	Phosphorylation		score4	IEDB neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	18083107, 18669648, 21127067, ...27869121
	Y264	Phosphorylation	Q9NR20 (DYRK4)	score3	neXtProt Signor UniProt	21127067
	S267	Phosphorylation		score1	PhosphoSitePlus
	Y356	Phosphorylation		score1	PhosphoSitePlus
	K360	Sumoylation		score1	PhosphoSitePlus
	K417	Ubiquitination		score1	PhosphoSitePlus
	S437	Phosphorylation		score1	PhosphoSitePlus
	T445	Phosphorylation		score1	PhosphoSitePlus
	T457	Phosphorylation		score1	PhosphoSitePlus

Q9NR20 (DYRK4) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q9NR20 (DYRK4)	Y264	score3	neXtProt Signor UniProt	21127067

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K71	N71	Biomuta		DOID:1324 / lung cancer [ cosmic ]
K72	E72	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
T211	S211	Biomuta		DOID:363 / uterine cancer [ cosmic ]
S213	F213	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S222	L222	Biomuta		[ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y356	C356	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S437	L437	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S437	W437	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]