iPTMnet Report for Q9NR19 (ACSS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NR19 / ACSA_HUMAN
Protein Name Acetyl-coenzyme A synthetase, cytoplasmic
Gene Name Name: ACSS2
Synonyms:ACAS2;
Organism Homo sapiens (Human)

PRO ID PR:Q9NR19
DAG View
PRO Name acetyl-coenzyme A synthetase, cytoplasmic (human)
Definition An acetyl-coenzyme A synthetase, cytoplasmic that is encoded in the genome of human.
Short Label hACSS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NR19 (ACSS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S30 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 18669648, 23186163, ...24275569
S36 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y47 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
C75 Methylation IEDB 31844290
K88 Ubiquitination PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 24275569, 18669648, ...35190642, 20068231
K271 Ubiquitination PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus   UniProt 19608861
K418 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
C459 Methylation IEDB 31844290
Y561 Phosphorylation PhosphoSitePlus
T644 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus   RLIMS-P 31750240, 28552616, 32922914
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 19413330, 17322306, 18088087, ...19562805, 18767875, 19651622, 18669648, 20166139, 19415658, 20068231
S267 Phosphorylation HPRD 17322306, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 19413330, 18088087, 19562805, ...18767875, 19651622, 18669648, 20166139, 19415658, 20068231
S267 Phosphorylation HPRD 17322306, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 N12 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K88 E88 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K227 E227 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K227 N227 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T264 P264 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S267 F267 Biomuta DOID:4159 / skin cancer [ cosmic ]
K271 M271 Biomuta DOID:4159 / skin cancer [ cosmic ]
K426 N426 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]