iPTMnet Report for Q9NQX3 (GPHN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQX3 / GEPH_HUMAN
Protein Name Gephyrin
Gene Name Name: GPHN
Synonyms:GPH,KIAA1385;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQX3
DAG View
PRO Name gephyrin (human)
Definition A gephyrin that is encoded in the genome of human.
Short Label hGPHN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQX3 (GPHN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R34 Methylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332, 24275569
S194 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332, 24275569
T198 Phosphorylation PhosphoSitePlus   UniProt 24275569
T199 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S250 O-Glycosylation GlyGen 31373491
S250 Phosphorylation PhosphoSitePlus
T260 O-Glycosylation GlyGen 32119511, 28657654, 31373491, ...35254053
S262 O-Glycosylation GlyGen 31373491
T265 O-Glycosylation GlyGen 32119511, 28657654, 31373491, ...35254053
T265 Phosphorylation PhosphoSitePlus
T266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
S268 Phosphorylation PhosphoSitePlus
S270 Phosphorylation P06493 (CDK1) , P49841 (GSK3B) , Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 23408424, 24165455, 22778260, ...33796945, 18669648, 21173228, 25093719
T276 Phosphorylation PhosphoSitePlus
S277 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S280 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T286 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16964243
S291 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 24275569
S319 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
T655 Phosphorylation PhosphoSitePlus
Y673 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T139 Phosphorylation HPRD 18491316
S147 Phosphorylation HPRD 20068231
S188 Phosphorylation HPRD 17322306, 18510355, 20166139, ...20068231
S194 Phosphorylation HPRD 17322306, 18510355, 19651622, ...20166139, 20068231
T198 Phosphorylation HPRD 17322306, 19651622, 20068231
T199 Phosphorylation HPRD 17081983
S200 Phosphorylation HPRD 17081983, 20068231
S250 Phosphorylation HPRD 20068231
T266 Phosphorylation HPRD 18669648, 16964243, 20068231
S268 Phosphorylation HPRD 20068231
S270 Phosphorylation HPRD 19413330, 18669648, 20068231
S277 Phosphorylation HPRD 18669648
S283 Phosphorylation HPRD 18669648
T286 Phosphorylation HPRD 18669648, 16964243
S305 Phosphorylation HPRD 20166139
T607 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T139 Phosphorylation HPRD 18491316
S147 Phosphorylation HPRD 20068231
S188 Phosphorylation HPRD 17322306, 18510355, 20166139, ...20068231
S194 Phosphorylation HPRD 17322306, 18510355, 19651622, ...20166139, 20068231
T198 Phosphorylation HPRD 17322306, 19651622, 20068231
T199 Phosphorylation HPRD 17081983
S200 Phosphorylation HPRD 17081983, 20068231
Y248 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S283 Phosphorylation HPRD 20068231
T299 Phosphorylation HPRD 18669648, 16964243, 20068231
S301 Phosphorylation HPRD 20068231
S303 Phosphorylation HPRD 19413330, 18669648, 20068231
S310 Phosphorylation HPRD 18669648
S316 Phosphorylation HPRD 18669648
T319 Phosphorylation HPRD 18669648, 16964243
S338 Phosphorylation HPRD 20166139
T640 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R34 H34 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
T139 M139 Biomuta DOID:1319 / brain cancer [ cosmic ]
S194 F194 Biomuta DOID:4159 / skin cancer [ cosmic ]
S250 F250 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S270 L270 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S283 F283 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S291 F291 Biomuta DOID:4159 / skin cancer [ cosmic ]
K296 N296 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S303 L303 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S319 Y319 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S480 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S571 L571 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T655 I655 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1319 / brain cancer [ cosmic ]