iPTMnet Report for Q9NQV7 (PRDM9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQV7 / PRDM9_HUMAN
Protein Name Histone-lysine N-methyltransferase PRDM9
Gene Name Name: PRDM9
Synonyms:PFM6;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQV7
DAG View
PRO Name histone-lysine N-methyltransferase PRDM9 (human)
Definition A histone-lysine N-methyltransferase PRDM9 that is encoded in the genome of human.
Short Label hPRDM9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQV7 (PRDM9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
T685 Phosphorylation PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
T713 Phosphorylation PhosphoSitePlus
T715 Phosphorylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus
T743 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
T769 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
T797 Phosphorylation PhosphoSitePlus
T799 Phosphorylation PhosphoSitePlus
T825 Phosphorylation PhosphoSitePlus
T827 Phosphorylation PhosphoSitePlus
K844 Acetylation PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
T855 Phosphorylation PhosphoSitePlus
T881 Phosphorylation PhosphoSitePlus
T883 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T18 A18 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T18 K18 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K21 N21 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K29 R29 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S128 Y128 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S128 F128 Biomuta DOID:4159 / skin cancer [ cosmic ]
S128 C128 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S129 G129 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T545 R545 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T545 I545 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T601 R601 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T601 I601 Biomuta [ cosmic ]
T603 R603 Biomuta DOID:363 / uterine cancer [ icgc ]
T685 R685 Biomuta [ cosmic ] DOID:184 / bone cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T685 I685 Biomuta [ cosmic ] DOID:184 / bone cancer [ cosmic ]
T687 K687 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T713 A713 Biomuta [ cosmic ]
T713 R713 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T715 K715 Biomuta DOID:1324 / lung cancer [ cosmic ]
S761 L761 Biomuta DOID:4159 / skin cancer [ cosmic ]
T769 R769 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T771 A771 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T797 A797 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T825 I825 Biomuta DOID:363 / uterine cancer [ icgc ]
T827 R827 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K844 T844 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T855 A855 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T855 K855 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]