iPTMnet Report for Q9NQU5 (PAK6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQU5 / PAK6_HUMAN
Protein Name Serine/threonine-protein kinase PAK 6
Gene Name Name: PAK6
Synonyms:PAK5;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQU5
DAG View
PRO Name serine/threonine-protein kinase PAK 6 (human)
Definition A serine/threonine-protein kinase PAK 6 that is encoded in the genome of human.
Short Label hPAK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQU5 (PAK6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T69 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
S165 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   Signor 15550393
S179 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
S531 Phosphorylation RLIMS-P 29311810
S560 Phosphorylation Q9NQU5 (PAK6) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 22339630, 29311810, 15550393, ...24352566, 14573606
T564 Phosphorylation P52564 (MAP2K6) phospho.ELM   PhosphoSitePlus 15550393
Y566 Phosphorylation P52564 (MAP2K6) phospho.ELM   PhosphoSitePlus   Signor 15550393
S616 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 19664994
S560 Phosphorylation HPRD 14573606


Q9NQU5 (PAK6) as PTM Enzyme



Substrate Site Score Source PMID
P10275 (AR) S579 PhosphoSitePlus 23132866
P53667 (LIMK1) T508 PhosphoSitePlus 25714010
Q00987 (MDM2) T158 PhosphoSitePlus 23132866
Q00987 (MDM2) S186 PhosphoSitePlus 23132866
Q92934 (BAD) S75 neXtProt 20054820
Q9BY11 (PACSIN1) S346 neXtProt   PhosphoSitePlus 24204982, 22371566
Q9NQU5 (PAK6) S560 neXtProt 14573606


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y129 F129 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y129 S129 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S347 F347 Biomuta DOID:4159 / skin cancer [ cosmic ]
T354 P354 Biomuta DOID:1612 / breast cancer [ cosmic ]
S360 N360 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K528 R528 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K528 N528 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T564 S564 Biomuta DOID:263 / kidney cancer [ cosmic ]